Rapid Access to Diverse Structures
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Photochemistry has seen a resurgence in recent years, primarily due to the discovery of photoredox catalysts and their uses in generating non-traditional reaction pathways to give structurally diverse and complex architectures, useful for the medicinal chemistry.¹
Photochemistry Conducted at HFR
Photochemical synthesis of Vitamin D3
1. Shaw, M. H. J. Org. Chem., 2016, 81, 6898, Photoredox Catalysis in Organic Chemistry, Acc. Chem. Res., 2016, themed issue, Bogdos, M. K, Pinnard, E, Murphy, J. A, Beilstein J. Org. Chem., 2018, 14, 2035.
2. Roth, H. D. Angew. Chem. Int. Ed. Eng., 1989, 28, 1193.
3. The production of Vitamin D3 is a commercial process, typically producing kg/day. We have used this conversion as a demonstration of HFR’s capabilities.
In order to circumvent this issue, HFR have designed a purpose-built flow reactor for the continuous photochemical synthesis of complex structures. This has been demonstrated by the relatively large-scale synthesis of Vitamin D3 (productivity >12 litres/day/lamp).
This setup has the benefits of not requiring external cooling due to the short residency time at the light source, increased photon absorption (>90% light captured) and is easily scalable by numbering up of reactors.