HFR, Your chemical innovation and commercialisation partner

High Force Research is an independently UK owned chemical R&D partner


Our clients rely on HFR to create specialist materials and develop robust synthetic manufacturing processes.

HFR can draw on extensive experience of applied chemistry across a wide range of industry sectors and academia.

Whether you are a multi-million dollar global client looking at repeat, reliable, small scale commercial production, or a start-up exploring possible applications of new ideas, High Force Research will support you in making it a reality.

Established in 1988, and based in the North East of England, HFR is independent and privately owned. Our partners use our materials in a range of applications; from Pharmaceuticals to Diagnostics, and Smart Materials to Organic Electronics. Due to our accumulated in-house knowledge we offer a versatile and information-led approach to your project, delivered from our UK research and production facilities.


HFR develop specialist materials for your industry

+  Chemical R & D
+  Route design
+  Process Development/Scale Up
+  Bespoke Contract Synthesis
+  Consistent quality manufacturing
+  Good Manufacturing Practice
+  Full Analytical Capability

+ GMP manufacture
+ GMP synthesis
+ Custom chemical synthesis
+ Custom organic synthesis
+ Research and Development
+ API manufacture

High Force Research manufacture advanced pharmaceutical ingredients to GMP standards for pre-clinical and clinical trials.

We can dedicate facilities and teams specifically to your project, working to your established pathways and quality management systems or we can work with you to develop proprietary methodologies.

HFR work with leading international institutes to nurture our talent and develop new processes, consequently our store of leading-edge knowledge is constantly refreshed. We have a proven track record in delivering to exact specifications, precisely when our partners need it.

We take pride in being your approachable and responsive outsourcing partner, providing and responding to feedback regularly, and above all supporting you all the way through your journey.


+  Literature studies
+  Route Design
+  Complex Synthesis
+  Specification (PQA)
+  Optimisation
+  Scale Up from Milligram to Kilo

+  Building blocks & intermediates
+  Patent analogues
+  Client proprietary compounds
+  Drug impurity compound
+  Metabolites

+  Full Analytical Capability
+  Method Development
+  Validation

+  Brokering
+  Commercialisation
+  Mentoring
+  Quality assurance

+  Manufacture
+  Analytical development
+  Analytical validation
+  Stability studies
+  Auditing
+  Reference substances

+  Repeat synthesis to agreed quality standard
+  Pre-clinical studies
+  API starting materials
+  Performance materials
+  Diagnostics