Flow chemistry can be used to gain access to synthetic intermediates or products that would otherwise be inaccessible using standard batch reactors. Furthermore, the reduced manufacture footprint, coupled with the inherent ability to minimise the presence of hazardous species at any one point, means that flow chemistry offers a significant opportunity for scalable quality-driven processes beyond High Force’s conventional batch reactors.
A recent example involved a nitration of natural fungal metabolite PF1022a used in the Bayer process to make anthelmintic cyclooctadepsipeptide, emodepside. The Bayer process uses batch nitration followed by reduction and alkylation to introduce the morpholino groups in the para/para configuration. However, a complex mixture is generated, requiring chromatography to separate the desired para/para regioisomer, making the cost of goods very high.