Flow Chemistry

Services   I   Technical Expertise

Flow processing allows exquisite control of mixing, heat transfer, reactive intermediates and hazardous reactions. High Force Research collaborates with New Path Molecular in order to innovate and optimise chemical processes through the application of flow chemistry techniques.

Flow Chemistry Techniques Conducted with New Path Molecular
+ Flow organometallics
+ Flow biotransformations
+ Gas-liquid flow reactions
+ Flow peptide synthesis
+ Flow electrochemistry
+ Flow photochemistry
Formed in 2015 as a spin out from the laboratories of Professor S. V. Ley, New Path Molecular is an innovation partner for the chemistry-using industries allowing access to functional molecules. The overarching aim of the partnership is to combine expertise in both batch and continuous flow chemistry to offer better synthetic solutions to the chemical community.

Flow chemistry can be used to gain access to synthetic intermediates or products that would otherwise be inaccessible using standard batch reactors. Furthermore, the reduced manufacture footprint, coupled with the inherent ability to minimise the presence of hazardous species at any one point, means that flow chemistry offers a significant opportunity for scalable quality-driven processes beyond High Force’s conventional batch reactors.

A recent example involved a nitration of natural fungal metabolite PF1022a used in the Bayer process to make anthelmintic cyclooctadepsipeptide, emodepside. The Bayer process uses batch nitration followed by reduction and alkylation to introduce the morpholino groups in the para/para configuration. However, a complex mixture is generated, requiring chromatography to separate the desired para/para regioisomer, making the cost of goods very high.

The Partial Synthesis of Emodepside

After a short feasibility study, it was discovered that by carrying out the reaction at low temperature the ratio of para/para to other isomers could be significantly improved. However, this reaction could not be scaled in batch without deterioration in the ratio due to unfavourable heat and mass transfer conditions.

By switching to a flow process, the optimised ratio could be maintained, meaning that the desired para/para product could be crystallised from the nitration product mixture, thus removing the requirement for expensive chromatographic purification. This novel methodology resulted in an improved and scalable process which was patent protected.

Continuous flow chemistry is set to have a significant impact across chemical manufacture, reflected in the 2019 FDA announcement that continuous manufacture was one of the most important tools for modernising the pharmaceutical industry. High Force Research have responded to this call and can now offer synthetic flow chemistry services for the manufacture of complex chemical targets.

If you have a project in mind and you think our facilities and expertise could help you then please contact us and talk to one of our team.

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Continuous flow chemistry is set to have a significant impact across chemical manufacture. High Force Research offer synthetic flow chemistry services for the manufacture of complex chemical targets.