HFR specialises in custom synthesis of organic compounds from grams to kilograms. We have extensive experience in making novel heterocyclics, aromatic and aliphatic compounds.
We have special expertise in making:
- MonoBoc Diamines
- Mono Protected Diamines
- Chiral Phenylalanine derivatives ( NSC technology )
- Fluoro organic compounds
- Aromatic hydrazines
- Dendrimer building blocks
Research Chemicals for Combinatorial Synthesis
Working typically on a confidential exclusive basis, we undertake synthesis at 10-100g scale of a wide range of functionalised heterocyclic, aromatic and aliphatic "monomers" and templates both for major pharma companies and combinatorial chemistry specialists.
Route selection and feasibility studies
From targets disclosed by discovery companies, we carry out a literature/theoretical study of possible or alternative routes leading on to initial feasibility study and then process development of the preferred route.
Synthesis of reference materials, metabolites and impurities
We carry out multi-step synthesis of reference materials' metabolites and impurities, from milligrams to hundreds of grams, for customers seeking to establish or maintain registration of their active compounds.
Specialised equipment includes:
- Stainless steel (2 litre and 7.5 litre) autoclaves for high pressure reactions.
- Glass (1 litre and 5 litre ) pressure vessels.
- Biotage pumped chromatography systems for purification